LABOTEST-BB LT00453193
trans-3-bromo-N-ethylcinnamamide
CAS: 58473-74-8
Molecular Formula: C11H12BrNO
LABOTEST-BB LT00453193 - Names and Identifiers
| Name | trans-3-bromo-N-ethylcinnamamide |
| Synonyms | D03513 cinromide LABOTEST-BB LT00453193 m-Bromo-N-ethylcinnamamide TRANS-3-BROMO-N-ETHYLCINNAMAMIDE trans-3-bromo-N-ethylcinnamamide (e)-3-(3-bromophenyl)-n-ethyl-2-propenamide |
| CAS | 58473-74-8 |
| EINECS | 806-290-2 |
| InChI | InChI=1/C11H12BrNO/c1-2-13-11(14)7-6-9-4-3-5-10(12)8-9/h3-8H,2H2,1H3,(H,13,14)/b7-6+ |
LABOTEST-BB LT00453193 - Physico-chemical Properties
| Molecular Formula | C11H12BrNO |
| Molar Mass | 254.12 |
| Density | 1.369±0.06 g/cm3(Predicted) |
| Melting Point | 89-91°C(lit.) |
| Boling Point | 417.5±45.0 °C(Predicted) |
| Flash Point | 206.3°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 3.53E-07mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Beige |
| Merck | 13,2334 |
| pKa | 14.59±0.46(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.591 |
| In vitro study | Cinromide (10-100 μM) inhibits 5-HT-induced contractions in rat fundus strips by 46%. Cinromide (100 μM) inhibits monoamine oxidase prepared from both liver and brain of rats. |
| In vivo study | Cinromide shows electroshock convulsion and leptazol(pentetrazo1)-induced convulsion in mice, with ED 50 s of 60 ± 11 mg/kg, 90 ± 15 mg/kg and 80 ± 15 mg/kg, 300 ± 61 mg/kg for i.p. and oral administrion, respectively. Cinromide produces a dose-related antileptazol activity with an ED 50 value of 58 ± 11 mg/kg by i.p. administration in rats. Furthermore, Cinromide (75 mg/kg) significantly elevates the amount of leptazol needed to induce clonic seizures in the intravenously infused leptazol-threshold test in rats. Cinromide (300 mg/kg, i.p) shows no sifnificant effect on the anaesthetized open-chested dogs after 4 h treatment, neither in conscious dogs after 5-h oral treatment with 300 and 600 mg/kg of Cinromide. Cinromide (40 mg/kg, i.v.) depresses the response of the neuron to the unconditioned maxillary nerve stimulus, increasing the latency and decreasing the number of spikes, and depresses the response of the neuron to the unconditioned maxillary nerve stimulus, increasing the latency and decreasing the number of spikes. Cinromide (20, 40, 80 mg/kg, i.v.) increases the latency of the unconditioned response and segmental inhibition dose-dependently. Cinromide decreases periventricular inhibition and EEG. |
LABOTEST-BB LT00453193 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | UC6314000 |
| Toxicity | LD50 in mice (mg/kg): 660 ±28 i.p.; 2277 ±250 orally (Soroko) |
LABOTEST-BB LT00453193 - Reference Information
| biological activity | cinrotide is an anticonvulsant. Cinrotide inhibits epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 of 0.5 μm. |
Last Update：2024-04-09 02:00:09
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CAS: 58473-74-8
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CAS: 58473-74-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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